A molecular origin of non-reciprocal interactions between interacting active catalysts

Niladri Sekhar Mandal, Ayusman Sen, R. Dean Astumian

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Recent work suggests that nonreciprocal interactions are universally present in living systems and constitute an important part of active matter. These interactions, that are in apparent violation of Newton's third law, break action/reaction symmetry and have been used to describe phenomena such as traveling waves, predator-prey dynamics, and swarming. Here, we elucidate how thermodynamic disequilibrium gives rise to non-reciprocal interactions in molecular systems where the individual molecules remain in mechanical equilibrium. We use a kinase/phosphatase enzyme pair as an illustrative example and show that non-reciprocal interactions between the two arise due to diffusion and kinetic asymmetries in the presence of self-generated substrate and product gradients. The force that kinase exerts on the phosphatase can be repulsive, whereas the phosphatase can exert an attractive force on the kinase. Notably, this chemotactic force is not introduced ad hoc; rather, the molecular origin of nonreciprocity is set by a combination of diffusion and kinetic asymmetry.

Original languageEnglish (US)
Pages (from-to)1147-1159
Number of pages13
JournalChem
Volume10
Issue number4
DOIs
StatePublished - Apr 11 2024

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Environmental Chemistry
  • General Chemical Engineering
  • Biochemistry, medical
  • Materials Chemistry

Cite this