@article{24adf7230706441c8f3bbe69a8cccaed,
title = "A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease",
abstract = "We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select for target proteins of interest and analyze them using molecular microscopy. Implementing our new streamlined microchip approach, we could directly visualize BRCA1 gene regulatory complexes from patient-derived cancer cells for the first time.",
author = "Gilmore, {Brian L.} and Winton, {Carly E.} and Demmert, {Andrew C.} and Tanner, {Justin R.} and Sam Bowman and Vasilea Karageorge and Kaya Patel and Zhi Sheng and Kelly, {Deborah F.}",
note = "Funding Information: This research is supported by funds from Virginia Tech, the Institute for Critical Technology and Applied Science (ICTAS) at Virginia Tech, the Commonwealth Health Research Board [2080914], the Concern Foundation [303872], and NCI/NIH [R01CA193578] to D.F.K. C.W. is funded through the ICTAS Doctoral Scholar{\textquoteright}s program at Virginia Tech and the Medical Research Scholar{\textquoteright}s program at the Virginia Tech Carilion Research Institute.",
year = "2015",
month = sep,
day = "23",
doi = "10.1038/srep14440",
language = "English (US)",
volume = "5",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}