A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice

Keyphrases

• Oxidative Stress 100%
• Brain Iron 100%
• H63D 100%
• HFE Gene 100%
• Iron Profile 100%
• Microglia 40%
• H-ferritin 40%
• L-ferritin 40%
• Neurodegenerative Diseases 40%
• Iron Storage 40%
• Brain Iron Homeostasis 40%
• Knock-in Mouse Model 20%
• Adaptive Mechanism 20%
• Protein Level 20%
• Metabolic Stress 20%
• Protein Expression 20%
• Heme oxygenase-1 (HO-1) 20%
• Mouse Brain 20%
• Adaptive Response 20%
• Transferrin 20%
• Iron Mobilization 20%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 20%
• Iron Concentration 20%
• Traditional Paradigm 20%
• HFE Polymorphism 20%
• Astrogliosis 20%
• Neurological Effects 20%
• Oxidized Proteins 20%
• Antioxidant Gene Expression 20%
• Iron Management 20%

Neuroscience

• Oxidative Stress 100%
• Ferritin 60%
• Microglia 40%
• Protein Expression 40%
• Neurodegenerative Disorder 40%
• Glutamic Acid 20%
• In Vivo 20%
• Prothrombin 20%
• Transferrin 20%
• Nuclear Factor 20%
• Adaptive Response 20%
• Antioxidant 20%
• Astrogliosis 20%
• Antiporter 20%
• Cystine 20%
• Mouse Brain 20%