A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2

Marie Claire Beckers; Eric Ernst; Scott Belcher; James Howe; Robert Levenson; Philippe Gros

doi:10.1006/geno.1996.0447

A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2

Marie Claire Beckers, Eric Ernst, Scott Belcher, James Howe, Robert Levenson, Philippe Gros

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an α- subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel α- subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.

Original language	English (US)
Pages (from-to)	202-205
Number of pages	4
Journal	Genomics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0447
State	Published - Aug 15 1996

All Science Journal Classification (ASJC) codes

Genetics

Access to Document

10.1006/geno.1996.0447

Cite this

@article{f4d95deb760a420293885857cf925e46,

title = "A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2",

abstract = "We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an α- subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel α- subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.",

author = "Beckers, {Marie Claire} and Eric Ernst and Scott Belcher and James Howe and Robert Levenson and Philippe Gros",

note = "Funding Information: M.-C.B. was supported by a postdoctoral fellowship from the Natural Sciences and Engineering Research Council of Canada. P.G. is supported by a career scientist award from the Medical Research Council of Canada and is an International Research Scholar from the Howard Hughes Medical Institute.",

year = "1996",

month = aug,

day = "15",

doi = "10.1006/geno.1996.0447",

language = "English (US)",

volume = "36",

pages = "202--205",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2

AU - Beckers, Marie Claire

AU - Ernst, Eric

AU - Belcher, Scott

AU - Howe, James

AU - Levenson, Robert

AU - Gros, Philippe

N1 - Funding Information: M.-C.B. was supported by a postdoctoral fellowship from the Natural Sciences and Engineering Research Council of Canada. P.G. is supported by a career scientist award from the Medical Research Council of Canada and is an International Research Scholar from the Howard Hughes Medical Institute.

PY - 1996/8/15

Y1 - 1996/8/15

N2 - We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an α- subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel α- subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.

AB - We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an α- subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel α- subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.

UR - http://www.scopus.com/inward/record.url?scp=0030586911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030586911&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.0447

DO - 10.1006/geno.1996.0447

M3 - Article

C2 - 8812438

AN - SCOPUS:0030586911

SN - 0888-7543

VL - 36

SP - 202

EP - 205

JO - Genomics

JF - Genomics

IS - 1

ER -

A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this