A new synthesis of double labeled [7, 9 ‐13C2] folic acid

Marlon Cowart; Christopher J. Falzone; Stephen J. Benkovic

doi:10.1002/jlcr.2580340109

A new synthesis of double labeled [7, 9 ‐¹³C₂] folic acid

Marlon Cowart, Christopher J. Falzone, Stephen J. Benkovic

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A convenient small scale chemical synthesis of double labeled folic acid with ¹³C at positions C‐7 and C‐9 is reported. [1,3‐¹³C₂] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.

Original language	English (US)
Pages (from-to)	67-71
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.2580340109
State	Published - Jan 1994

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.2580340109

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title = "A new synthesis of double labeled [7, 9 ‐13C2] folic acid",

abstract = "A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C‐7 and C‐9 is reported. [1,3‐13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.",

author = "Marlon Cowart and Falzone, {Christopher J.} and Benkovic, {Stephen J.}",

year = "1994",

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AU - Benkovic, Stephen J.

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N2 - A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C‐7 and C‐9 is reported. [1,3‐13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.

AB - A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C‐7 and C‐9 is reported. [1,3‐13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.

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JF - Journal of Labelled Compounds and Radiopharmaceuticals

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ER -

A new synthesis of double labeled [7, 9 ‐¹³C₂] folic acid

Abstract

All Science Journal Classification (ASJC) codes

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