A new synthesis of double labeled [7, 9 ‐13C2] folic acid

Marlon Cowart; Christopher J. Falzone; Stephen J. Benkovic

doi:10.1002/jlcr.2580340109

A new synthesis of double labeled [7, 9 ‐¹³C₂] folic acid

Marlon Cowart
, Christopher J. Falzone
, Stephen J. Benkovic

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A convenient small scale chemical synthesis of double labeled folic acid with ¹³C at positions C‐7 and C‐9 is reported. [1,3‐¹³C₂] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.

Original language	English (US)
Pages (from-to)	67-71
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.2580340109
State	Published - Jan 1994

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.2580340109

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title = "A new synthesis of double labeled [7, 9 ‐13C2] folic acid",

abstract = "A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C‐7 and C‐9 is reported. [1,3‐13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.",

author = "Marlon Cowart and Falzone, \{Christopher J.\} and Benkovic, \{Stephen J.\}",

year = "1994",

month = jan,

doi = "10.1002/jlcr.2580340109",

language = "English (US)",

volume = "34",

pages = "67--71",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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publisher = "John Wiley and Sons Ltd",

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AU - Cowart, Marlon

AU - Falzone, Christopher J.

AU - Benkovic, Stephen J.

PY - 1994/1

Y1 - 1994/1

N2 - A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C‐7 and C‐9 is reported. [1,3‐13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.

AB - A convenient small scale chemical synthesis of double labeled folic acid with 13C at positions C‐7 and C‐9 is reported. [1,3‐13C2] acetone was converted into folic acid in two steps, with [1, 1, 3]‐trichloroacetone as the labeled intermediate.

UR - https://www.scopus.com/pages/publications/0027958288

UR - https://www.scopus.com/pages/publications/0027958288#tab=citedBy

U2 - 10.1002/jlcr.2580340109

DO - 10.1002/jlcr.2580340109

M3 - Article

AN - SCOPUS:0027958288

SN - 0362-4803

VL - 34

SP - 67

EP - 71

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 1

ER -

A new synthesis of double labeled [7, 9 ‐¹³C₂] folic acid

Abstract

All Science Journal Classification (ASJC) codes

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