A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically Patterned 6π-2-azatriene electrocyclization

Matthew L. Meketa; Steven M. Weinreb

doi:10.1021/ol063038a

A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically Patterned 6π-2-azatriene electrocyclization

Matthew L. Meketa, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

(Chemical Equation Presented) A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6π-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.

Original language	English (US)
Pages (from-to)	853-855
Number of pages	3
Journal	Organic Letters
Volume	9
Issue number	5
DOIs	https://doi.org/10.1021/ol063038a
State	Published - Mar 1 2007

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol063038a

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title = "A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically Patterned 6π-2-azatriene electrocyclization",

abstract = "(Chemical Equation Presented) A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6π-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.",

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AU - Weinreb, Steven M.

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N2 - (Chemical Equation Presented) A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6π-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.

AB - (Chemical Equation Presented) A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6π-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.

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U2 - 10.1021/ol063038a

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JO - Organic Letters

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ER -

A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically Patterned 6π-2-azatriene electrocyclization

Abstract

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UN SDGs

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