A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro

Keyphrases

• 3-hydroxy-3-methylglutaryl-CoA Reductase 40%
• Biphenyl 20%
• Bisphosphonates 100%
• Cell Viability 60%
• Cholesterol Biosynthesis 40%
• Cholesterol Synthesis 20%
• Co-treatment 20%
• Coenzyme A 40%
• Dimethyl 20%
• Farnesyl Pyrophosphate 20%
• FPP® 80%
• Geranylgeranyl Diphosphate Synthase 40%
• HepG2 Cells 20%
• High Concentration 20%
• Intracellular Accumulation 20%
• Isoprenoids 20%
• Lovastatin 100%
• Mevalonate Pathway 20%
• Potent Inhibitor 20%
• Protein Geranylgeranylation 20%
• Protein Prenylation 40%
• Specific Inhibitor 20%
• Squalene Synthase 100%
• Statins 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Biphenyl 20%
• Bisphosphonic Acid Derivative 100%
• Cell Viability 60%
• Farnesyl Diphosphate 20%
• Geranyltransferase 40%
• HMG-CoA 40%
• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 20%
• Isoprenoid 20%
• Mevalonic Acid 20%
• Mevinolin 100%
• Oxidoreductase 40%
• Sodium Chloride 20%
• Squalene Synthase 100%
• Statin (Protein) 100%
• Zoledronic Acid 100%

Biochemistry, Genetics and Molecular Biology

• Cell Viability 50%
• Cholesterol Synthesis 50%
• Geranylgeranylation 16%
• HMG-CoA 33%
• Lovastatin 83%
• Mevalonate Pathway 16%
• Oxidoreductase 33%
• Protein Prenylation 33%
• Pyrophosphate 50%
• Reductase 33%
• Statin 100%
• Synthase 100%