TY - JOUR
T1 - A novel copper (i) mediated, symmetrical coupling procedure for alkyl, aryl, benzyl, and thiophenyl dihalides
AU - Johnson, David K.
AU - Ciavarri, Jeffrey P.
AU - Ishmael, Faoud T.
AU - Schillinger, Kurl J.
AU - van Geel, Thomas A.P.
AU - Stratton, Stephen M.
PY - 1995/11/20
Y1 - 1995/11/20
N2 - A comparative study of Li2CuCl4 vs Li2CuCl3 mediated mono-coupling reactions of dihalide substrates with allylmangnesium bromide is reported. Higher yields were obtained with Li2CuCl3 and the following trends in halide reactivity were observed Br > Cl for alkyl, aryl, and thiophenyl dihalides. and benzyl halide > phenyl halide. Utilizing these trends, a symmetrical coupling procedure for alkyl. aryl benzyl and thiophenyl dihalides, simply carried out by combining the dihalide with metallic magnesium and Li2CuCl4 is reported.
AB - A comparative study of Li2CuCl4 vs Li2CuCl3 mediated mono-coupling reactions of dihalide substrates with allylmangnesium bromide is reported. Higher yields were obtained with Li2CuCl3 and the following trends in halide reactivity were observed Br > Cl for alkyl, aryl, and thiophenyl dihalides. and benzyl halide > phenyl halide. Utilizing these trends, a symmetrical coupling procedure for alkyl. aryl benzyl and thiophenyl dihalides, simply carried out by combining the dihalide with metallic magnesium and Li2CuCl4 is reported.
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U2 - 10.1016/0040-4039(95)01850-H
DO - 10.1016/0040-4039(95)01850-H
M3 - Article
AN - SCOPUS:0028827140
SN - 0040-4039
VL - 36
SP - 8565
EP - 8568
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 47
ER -