Abstract
A novel elastomer, poly(1,10-decanediol-co-citric acid) (PDC), and its potential use in blood vessel tissue engineering were studied. The elastomer was based on polycondensation of citric acid and a linear aliphatic diol. The elastomer was characterized by conducting mechanical testing, burst pressure measurement, and Fourier transform infrared (FTIR) analysis. Relative degradation in 0.1 M NaOH and biocompatibility evaluation in vitro with human aortic smooth muscle (HASMC) and endothelial cells (HAEC) and in vivo using subcutaneous implantation in rats were also carried out. PDC was found to exhibit excellent biocompatibility both in vitro and in vivo, and burst pressure on the order of native blood vessels.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| Pages | 1674 |
| Number of pages | 1 |
| State | Published - 2004 |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country/Territory | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
All Science Journal Classification (ASJC) codes
- General Engineering