A novel immuno sensing technique based on the thermal properties of biochemicals

Yuyan Zhang; Srinivas Tadigadapa

doi:10.1109/ICSENS.2005.1597632

A novel immuno sensing technique based on the thermal properties of biochemicals

Yuyan Zhang, Srinivas Tadigadapa

Materials Research Institute (MRI)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

A new and independent method to investigate biological reactions and their products based upon the accurate and real-time measurement of the thermal conductivity of the reacting samples is presented. A micromachined thermopile based thermal sensor integrated with a planar heater and microfluidic channel has been fabricated for these measurements. The device was calibrated by measuring the thermal conductivity of standard fluids such as DI water and isopropyl alcohol. The calibrated device was then used to measure the thermal properties of biological molecules such as glucose, urea, Bovine Serum Albumin (BSA), Human Fibrinogen (HF), their antibodies, and the bound product. To the best of our knowledge, this is the first report of the observation of the real-time monitoring of antibody-antigen binding based on the change in the thermal properties of the reacting fluids.

Original language	English (US)
Title of host publication	Proceedings of the Fourth IEEE Conference on Sensors 2005
Pages	41-44
Number of pages	4
DOIs	https://doi.org/10.1109/ICSENS.2005.1597632
State	Published - 2005
Event	Fourth IEEE Conference on Sensors 2005 - Irvine, CA, United States Duration: Oct 31 2005 → Nov 3 2005

Publication series

Name	Proceedings of IEEE Sensors
Volume	2005

Other

Other	Fourth IEEE Conference on Sensors 2005
Country/Territory	United States
City	Irvine, CA
Period	10/31/05 → 11/3/05

All Science Journal Classification (ASJC) codes

Electrical and Electronic Engineering

Access to Document

10.1109/ICSENS.2005.1597632

Cite this

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title = "A novel immuno sensing technique based on the thermal properties of biochemicals",

abstract = "A new and independent method to investigate biological reactions and their products based upon the accurate and real-time measurement of the thermal conductivity of the reacting samples is presented. A micromachined thermopile based thermal sensor integrated with a planar heater and microfluidic channel has been fabricated for these measurements. The device was calibrated by measuring the thermal conductivity of standard fluids such as DI water and isopropyl alcohol. The calibrated device was then used to measure the thermal properties of biological molecules such as glucose, urea, Bovine Serum Albumin (BSA), Human Fibrinogen (HF), their antibodies, and the bound product. To the best of our knowledge, this is the first report of the observation of the real-time monitoring of antibody-antigen binding based on the change in the thermal properties of the reacting fluids.",

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doi = "10.1109/ICSENS.2005.1597632",

language = "English (US)",

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series = "Proceedings of IEEE Sensors",

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booktitle = "Proceedings of the Fourth IEEE Conference on Sensors 2005",

note = "Fourth IEEE Conference on Sensors 2005 ; Conference date: 31-10-2005 Through 03-11-2005",

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AU - Zhang, Yuyan

AU - Tadigadapa, Srinivas

PY - 2005

Y1 - 2005

N2 - A new and independent method to investigate biological reactions and their products based upon the accurate and real-time measurement of the thermal conductivity of the reacting samples is presented. A micromachined thermopile based thermal sensor integrated with a planar heater and microfluidic channel has been fabricated for these measurements. The device was calibrated by measuring the thermal conductivity of standard fluids such as DI water and isopropyl alcohol. The calibrated device was then used to measure the thermal properties of biological molecules such as glucose, urea, Bovine Serum Albumin (BSA), Human Fibrinogen (HF), their antibodies, and the bound product. To the best of our knowledge, this is the first report of the observation of the real-time monitoring of antibody-antigen binding based on the change in the thermal properties of the reacting fluids.

AB - A new and independent method to investigate biological reactions and their products based upon the accurate and real-time measurement of the thermal conductivity of the reacting samples is presented. A micromachined thermopile based thermal sensor integrated with a planar heater and microfluidic channel has been fabricated for these measurements. The device was calibrated by measuring the thermal conductivity of standard fluids such as DI water and isopropyl alcohol. The calibrated device was then used to measure the thermal properties of biological molecules such as glucose, urea, Bovine Serum Albumin (BSA), Human Fibrinogen (HF), their antibodies, and the bound product. To the best of our knowledge, this is the first report of the observation of the real-time monitoring of antibody-antigen binding based on the change in the thermal properties of the reacting fluids.

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M3 - Conference contribution

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T3 - Proceedings of IEEE Sensors

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BT - Proceedings of the Fourth IEEE Conference on Sensors 2005

T2 - Fourth IEEE Conference on Sensors 2005

Y2 - 31 October 2005 through 3 November 2005

ER -

A novel immuno sensing technique based on the thermal properties of biochemicals

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