@article{1d8e9bfa30854bd99a4b871d8c1185d6,
title = "A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project",
abstract = "An understanding of the ethical underpinnings of human subjects research that involves some risk to participants without anticipated direct clinical benefit—such as the kidney biopsy procedure as part of the Kidney Precision Medicine Project (KPMP)—requires a critical examination of the risks as well as the diverse set of countervailing potential benefits to participants. This kind of deliberation has been foundational to the development and conduct of the KPMP. Herein, we use illustrative features of this research paradigm to develop a more comprehensive conceptualization of the types of benefits that may be important to research participants, including respecting pluralistic values, supporting the opportunity to act altruistically, and enhancing benefits to a participant's community. This approach may serve as a model to help researchers, ethicists, and regulators to identify opportunities to better respect and support participants in future research that entails some risk to these participants as well as to improve the quality of research for people with kidney disease.",
author = "{Kidney Precision Medicine Project} and Butler, {Catherine R.} and Appelbaum, {Paul S.} and Heather Ascani and Mark Aulisio and Campbell, {Catherine E.} and {de Boer}, {Ian H.} and Dighe, {Ashveena L.} and Hall, {Daniel E.} and Jonathan Himmelfarb and Richard Knight and Karla Mehl and Raghavan Murugan and Rosas, {Sylvia E.} and Sedor, {John R.} and O'Toole, {John F.} and Tuttle, {Katherine R.} and Waikar, {Sushrut S.} and Michael Freeman and Theodore Alexandrov and Alpers, {Charles E.} and Anderton, {Christopher R.} and Joseph Ardayfio and Tanima Arora and El-Achkar, {Tarek M.} and Azeloglu, {Evren U.} and Olivia Balderes and Balis, {Ulysses G.J.} and Shweta Bansal and Barasch, {Jonathan M.} and Daria Barwinska and Jack Bebiak and Blanc, {Victoria M.} and Blank, {Kristina N.} and Bomback, {Andrew S.} and Brown, {Keith D.} and Bush, {William S.} and Taneisha Campbell and Canetta, {Pietro A.} and Jonas Carson and Leslie Cooperman and Crawford, {Dana C.} and D'Agati, {Vivette D.} and Dagher, {Pierre C.} and Stephen Daniel and Frederick Dowd and Dunn, {Kenneth W.} and Eadon, {Michael T.} and Sean Eddy and Elder, {Michele M.} and Jennifer Schaub",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2022",
month = jul,
doi = "10.1053/j.ajkd.2021.10.006",
language = "English (US)",
volume = "80",
pages = "132--138",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders",
number = "1",
}