A phase I study of hepatic arterial infusion using difluoromethylornithine

Allan Lipton; Harold A. Harvey; Jerry Glenn; William A. Weidner; Melvin Strauss; Sharon E. Miller; Jerlynn B. Taylor; Deborah White‐Hershey; John L.R. Barlow

doi:10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5

A phase I study of hepatic arterial infusion using difluoromethylornithine

Allan Lipton
, Harold A. Harvey
, Jerry Glenn
, William A. Weidner
, Melvin Strauss
, Sharon E. Miller
, Jerlynn B. Taylor
, Deborah White‐Hershey
, John L.R. Barlow

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Ten patients with metastatic disease to the liver were treated with difluoromethylornithine (DFMO) administered by continuous hepatic arterial infusion. Two of nine evaluable patients had an objective partial response. Stable disease was recorded in three patients. Ototoxicity was encountered in all patients who received a daily dose of DFMO equal to or greater than 1.0 g/m².

Original language	English (US)
Pages (from-to)	433-437
Number of pages	5
Journal	Cancer
Volume	63
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5
State	Published - Feb 1 1989

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5

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title = "A phase I study of hepatic arterial infusion using difluoromethylornithine",

abstract = "Ten patients with metastatic disease to the liver were treated with difluoromethylornithine (DFMO) administered by continuous hepatic arterial infusion. Two of nine evaluable patients had an objective partial response. Stable disease was recorded in three patients. Ototoxicity was encountered in all patients who received a daily dose of DFMO equal to or greater than 1.0 g/m2.",

author = "Allan Lipton and Harvey, \{Harold A.\} and Jerry Glenn and Weidner, \{William A.\} and Melvin Strauss and Miller, \{Sharon E.\} and Taylor, \{Jerlynn B.\} and Deborah White‐Hershey and Barlow, \{John L.R.\}",

year = "1989",

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doi = "10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5",

language = "English (US)",

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T1 - A phase I study of hepatic arterial infusion using difluoromethylornithine

AU - Lipton, Allan

AU - Harvey, Harold A.

AU - Glenn, Jerry

AU - Weidner, William A.

AU - Strauss, Melvin

AU - Miller, Sharon E.

AU - Taylor, Jerlynn B.

AU - White‐Hershey, Deborah

AU - Barlow, John L.R.

PY - 1989/2/1

Y1 - 1989/2/1

N2 - Ten patients with metastatic disease to the liver were treated with difluoromethylornithine (DFMO) administered by continuous hepatic arterial infusion. Two of nine evaluable patients had an objective partial response. Stable disease was recorded in three patients. Ototoxicity was encountered in all patients who received a daily dose of DFMO equal to or greater than 1.0 g/m2.

AB - Ten patients with metastatic disease to the liver were treated with difluoromethylornithine (DFMO) administered by continuous hepatic arterial infusion. Two of nine evaluable patients had an objective partial response. Stable disease was recorded in three patients. Ototoxicity was encountered in all patients who received a daily dose of DFMO equal to or greater than 1.0 g/m2.

UR - https://www.scopus.com/pages/publications/0024591008

UR - https://www.scopus.com/pages/publications/0024591008#tab=citedBy

U2 - 10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5

DO - 10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5

M3 - Article

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AN - SCOPUS:0024591008

SN - 0008-543X

VL - 63

SP - 433

EP - 437

JO - Cancer

JF - Cancer

IS - 3

ER -

A phase I study of hepatic arterial infusion using difluoromethylornithine

Abstract

All Science Journal Classification (ASJC) codes

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