Abstract
Background: Dystonia often has inconsistent benefits and requires more energy-demanding DBS settings. Studies suggest that squared biphasic pulses could provide significant clinical benefit; however, dystonia patients have not been explored. Objectives: To assess safety and tolerability of square biphasic DBS in dystonia patients. Methods: This study included primary generalized or cervical dystonia patients with bilateral GPi DBS. Square biphasic pulses were implemented and patients were assessed at baseline, immediately postwashout, post–30-minute washout, 1 hour post- and 2 hours postinitiation of investigational settings. Results: Ten participants completed the study. There were no patient-reported or clinician-observed side effects. There was improvement across time on the Toronto Western Spasmodic Torticollis Rating Scale (χ2 = 10.7; P = 0.031). Similar improvement was detected in objective gait measurements. Conclusions: Square biphasic stimulation appears safe and feasible in dystonia patients with GPi DBS. Further studies are needed to evaluate possible effectiveness particularly in cervical and gait features.
Original language | English (US) |
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Pages (from-to) | 615-618 |
Number of pages | 4 |
Journal | Movement Disorders |
Volume | 32 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2017 |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology