A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection

Yin Ting Yeh; Huaguang Lu; Si Yang Zheng; And Mauricio Terrones

doi:10.1109/EMBC.2018.8513515

A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection

Yin Ting Yeh, Huaguang Lu, Si Yang Zheng, And Mauricio Terrones

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has 117 nm average gap size and 97 porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50 μL of PBS containing 6.3 × 104 counts of lentivirus particles in 10 minutes with 97 of capture efficiency, quantified by the cell infectious titration technique.

Original language	English (US)
Title of host publication	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	6072-6075
Number of pages	4
ISBN (Electronic)	9781538636466
DOIs	https://doi.org/10.1109/EMBC.2018.8513515
State	Published - Oct 26 2018
Event	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States Duration: Jul 18 2018 → Jul 21 2018

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2018-July
ISSN (Print)	1557-170X

Other

Other	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Country/Territory	United States
City	Honolulu
Period	7/18/18 → 7/21/18

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/EMBC.2018.8513515

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Yeh, Y. T., Lu, H., Zheng, S. Y., & Terrones, A. M. (2018). A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 6072-6075). Article 8513515 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8513515

Yeh, Yin Ting ; Lu, Huaguang ; Zheng, Si Yang et al. / A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 6072-6075 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection",

abstract = "Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has 117 nm average gap size and 97 porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50 μL of PBS containing 6.3 × 104 counts of lentivirus particles in 10 minutes with 97 of capture efficiency, quantified by the cell infectious titration technique.",

author = "Yeh, {Yin Ting} and Huaguang Lu and Zheng, {Si Yang} and Terrones, {And Mauricio}",

year = "2018",

month = oct,

day = "26",

doi = "10.1109/EMBC.2018.8513515",

language = "English (US)",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "6072--6075",

booktitle = "40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018",

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note = "40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 ; Conference date: 18-07-2018 Through 21-07-2018",

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Yeh, YT, Lu, H, Zheng, SY & Terrones, AM 2018, A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8513515, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2018-July, Institute of Electrical and Electronics Engineers Inc., pp. 6072-6075, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18. https://doi.org/10.1109/EMBC.2018.8513515

A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection. / Yeh, Yin Ting; Lu, Huaguang; Zheng, Si Yang et al.
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 6072-6075 8513515 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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PY - 2018/10/26

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N2 - Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has 117 nm average gap size and 97 porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50 μL of PBS containing 6.3 × 104 counts of lentivirus particles in 10 minutes with 97 of capture efficiency, quantified by the cell infectious titration technique.

AB - Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has 117 nm average gap size and 97 porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50 μL of PBS containing 6.3 × 104 counts of lentivirus particles in 10 minutes with 97 of capture efficiency, quantified by the cell infectious titration technique.

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Y2 - 18 July 2018 through 21 July 2018

ER -

Yeh YT, Lu H, Zheng SY, Terrones AM. A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 6072-6075. 8513515. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2018.8513515

A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection

Abstract

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