A potential role for nitric oxide in myocardial stunning

B. G. Hattler; J. Gorcsan; N. Shah; C. V. Oddis; T. R. Billiar; R. L. Simmons; M. S. Finkel

doi:10.1111/jocs.1994.9.3s.425

A potential role for nitric oxide in myocardial stunning

B. G. Hattler, J. Gorcsan, N. Shah, C. V. Oddis, T. R. Billiar, R. L. Simmons, M. S. Finkel

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.

Original language	English (US)
Pages (from-to)	425-429
Number of pages	5
Journal	Journal of Cardiac Surgery
Volume	9
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1111/jocs.1994.9.3s.425
State	Published - 1994

All Science Journal Classification (ASJC) codes

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

Access to Document

10.1111/jocs.1994.9.3s.425

Cite this

@article{e12af75bda534d27afbd37e13bab0bfd,

title = "A potential role for nitric oxide in myocardial stunning",

abstract = "Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.",

author = "Hattler, \{B. G.\} and J. Gorcsan and N. Shah and Oddis, \{C. V.\} and Billiar, \{T. R.\} and Simmons, \{R. L.\} and Finkel, \{M. S.\}",

year = "1994",

doi = "10.1111/jocs.1994.9.3s.425",

language = "English (US)",

volume = "9",

pages = "425--429",

journal = "Journal of Cardiac Surgery",

issn = "0886-0440",

publisher = "John Wiley and Sons Inc.",

number = "3 SUPPL.",

}

TY - JOUR

T1 - A potential role for nitric oxide in myocardial stunning

AU - Hattler, B. G.

AU - Gorcsan, J.

AU - Shah, N.

AU - Oddis, C. V.

AU - Billiar, T. R.

AU - Simmons, R. L.

AU - Finkel, M. S.

PY - 1994

Y1 - 1994

N2 - Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.

AB - Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.

UR - https://www.scopus.com/pages/publications/0028198880

UR - https://www.scopus.com/inward/citedby.url?scp=0028198880&partnerID=8YFLogxK

U2 - 10.1111/jocs.1994.9.3s.425

DO - 10.1111/jocs.1994.9.3s.425

M3 - Article

C2 - 7520788

AN - SCOPUS:0028198880

SN - 0886-0440

VL - 9

SP - 425

EP - 429

JO - Journal of Cardiac Surgery

JF - Journal of Cardiac Surgery

IS - 3 SUPPL.

ER -

A potential role for nitric oxide in myocardial stunning

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this