TY - JOUR
T1 - A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26
AU - Flarend, R.
AU - Bin, T.
AU - Elmore, D.
AU - Hem, S. L.
N1 - Funding Information:
The authors wish to thank the Cosmetic, Toiletry and Fragrance Association for their assistance in the planning of this study. This work was funded in part by the Showalter Trust. PRIME Lab is supported by The National Science Foundation. This study was approved by and performed in accordance with the Committee on the Use of Human Research Subjects, Purdue University.
PY - 2001
Y1 - 2001
N2 - Aluminium chlorohydrate (ACH), the active ingredient in many antiperspirants, was labeled with the radioisotope 26Al. The labeled ACH was then fractionated into about 100 samples using gel filtration chromatography. Each fraction was analyzed for 26Al and total aluminium content. Aluminium-26 was only detected in the fractions that also contained aluminium, which verified that the ACH was uniformly labeled. 84 mg of the labeled ACH was then applied to a single underarm of two adult subjects with blood and urine samples being collected over 7 weeks. Tape-stripping and mild washings of the skin were also collected for the first 6 days. Results indicate that only 0.012% of the applied aluminium was absorbed through the skin. At this rate, about 4 μg of aluminium is absorbed from a single use of ACH on both underarms. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period. Therefore, a one-time use of ACH applied to the skin is not a significant contribution to the body burden of aluminium.
AB - Aluminium chlorohydrate (ACH), the active ingredient in many antiperspirants, was labeled with the radioisotope 26Al. The labeled ACH was then fractionated into about 100 samples using gel filtration chromatography. Each fraction was analyzed for 26Al and total aluminium content. Aluminium-26 was only detected in the fractions that also contained aluminium, which verified that the ACH was uniformly labeled. 84 mg of the labeled ACH was then applied to a single underarm of two adult subjects with blood and urine samples being collected over 7 weeks. Tape-stripping and mild washings of the skin were also collected for the first 6 days. Results indicate that only 0.012% of the applied aluminium was absorbed through the skin. At this rate, about 4 μg of aluminium is absorbed from a single use of ACH on both underarms. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period. Therefore, a one-time use of ACH applied to the skin is not a significant contribution to the body burden of aluminium.
UR - http://www.scopus.com/inward/record.url?scp=0035084124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035084124&partnerID=8YFLogxK
U2 - 10.1016/S0278-6915(00)00118-6
DO - 10.1016/S0278-6915(00)00118-6
M3 - Article
C2 - 11267710
AN - SCOPUS:0035084124
SN - 0278-6915
VL - 39
SP - 163
EP - 168
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 2
ER -