A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Andres V. Ardisson Korat; Yu Han Chiu; Kimberly A. Bertrand; Shumin Zhang; Mara M. Epstein; Bernard A. Rosner; Stephanie Chiuve; Hannia Campos; Edward L. Giovannucci; Jorge E. Chavarro; Brenda M. Birmann

doi:10.1080/10428194.2022.2131419

A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Andres V. Ardisson Korat, Yu Han Chiu, Kimberly A. Bertrand, Shumin Zhang, Mara M. Epstein, Bernard A. Rosner, Stephanie Chiuve, Hannia Campos, Edward L. Giovannucci, Jorge E. Chavarro, Brenda M. Birmann

Research output: Contribution to journal › Article › peer-review

Abstract

Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03–1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23–4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.

Original language	English (US)
Pages (from-to)	3351-3361
Number of pages	11
Journal	Leukemia and Lymphoma
Volume	63
Issue number	14
DOIs	https://doi.org/10.1080/10428194.2022.2131419
State	Published - 2022

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/10428194.2022.2131419

Cite this

Ardisson Korat, A. V., Chiu, Y. H., Bertrand, K. A., Zhang, S., Epstein, M. M., Rosner, B. A., Chiuve, S., Campos, H., Giovannucci, E. L., Chavarro, J. E., & Birmann, B. M. (2022). A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma. Leukemia and Lymphoma, 63(14), 3351-3361. https://doi.org/10.1080/10428194.2022.2131419

@article{7e425a81d3874a79ac9d0ead9f0dc8e4,

title = "A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma",

abstract = "Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses{\textquoteright} Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03–1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23–4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.",

author = "{Ardisson Korat}, {Andres V.} and Chiu, {Yu Han} and Bertrand, {Kimberly A.} and Shumin Zhang and Epstein, {Mara M.} and Rosner, {Bernard A.} and Stephanie Chiuve and Hannia Campos and Giovannucci, {Edward L.} and Chavarro, {Jorge E.} and Birmann, {Brenda M.}",

note = "Publisher Copyright: {\textcopyright} 2022 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2022",

doi = "10.1080/10428194.2022.2131419",

language = "English (US)",

volume = "63",

pages = "3351--3361",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Informa Healthcare",

number = "14",

}

Ardisson Korat, AV, Chiu, YH, Bertrand, KA, Zhang, S, Epstein, MM, Rosner, BA, Chiuve, S, Campos, H, Giovannucci, EL, Chavarro, JE & Birmann, BM 2022, 'A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma', Leukemia and Lymphoma, vol. 63, no. 14, pp. 3351-3361. https://doi.org/10.1080/10428194.2022.2131419

TY - JOUR

T1 - A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

AU - Ardisson Korat, Andres V.

AU - Chiu, Yu Han

AU - Bertrand, Kimberly A.

AU - Zhang, Shumin

AU - Epstein, Mara M.

AU - Rosner, Bernard A.

AU - Chiuve, Stephanie

AU - Campos, Hannia

AU - Giovannucci, Edward L.

AU - Chavarro, Jorge E.

AU - Birmann, Brenda M.

PY - 2022

Y1 - 2022

N2 - Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03–1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23–4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.

AB - Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03–1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23–4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.

UR - http://www.scopus.com/inward/record.url?scp=85140109561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85140109561&partnerID=8YFLogxK

U2 - 10.1080/10428194.2022.2131419

DO - 10.1080/10428194.2022.2131419

M3 - Article

C2 - 36255154

AN - SCOPUS:85140109561

SN - 1042-8194

VL - 63

SP - 3351

EP - 3361

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 14

ER -

A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this