A quantitative trait locus associated with cognitive ability in children

M. J. Chorney; K. Chorney; N. Seese; M. J. Owen; J. Daniels; P. McGuffin; L. A. Thompson; D. K. Detterman; C. Benbow; D. Lubinski; T. Eley; R. Plomin

doi:10.1111/1467-9280.00032

A quantitative trait locus associated with cognitive ability in children

M. J. Chorney, K. Chorney, N. Seese, M. J. Owen, J. Daniels, P. McGuffin, L. A. Thompson, D. K. Detterman, C. Benbow, D. Lubinski, T. Eley, R. Plomin

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113 Scopus citations

Abstract

Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156; average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).

Original language	English (US)
Pages (from-to)	159-166
Number of pages	8
Journal	Psychological Science
Volume	9
Issue number	3
DOIs	https://doi.org/10.1111/1467-9280.00032
State	Published - May 1998

All Science Journal Classification (ASJC) codes

General Psychology

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10.1111/1467-9280.00032

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title = "A quantitative trait locus associated with cognitive ability in children",

abstract = "Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156; average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).",

author = "Chorney, {M. J.} and K. Chorney and N. Seese and Owen, {M. J.} and J. Daniels and P. McGuffin and Thompson, {L. A.} and Detterman, {D. K.} and C. Benbow and D. Lubinski and T. Eley and R. Plomin",

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doi = "10.1111/1467-9280.00032",

language = "English (US)",

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AU - Chorney, M. J.

AU - Chorney, K.

AU - Seese, N.

AU - Owen, M. J.

AU - Daniels, J.

AU - McGuffin, P.

AU - Thompson, L. A.

AU - Detterman, D. K.

AU - Benbow, C.

AU - Lubinski, D.

AU - Eley, T.

AU - Plomin, R.

PY - 1998/5

Y1 - 1998/5

N2 - Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156; average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).

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A quantitative trait locus associated with cognitive ability in children

Abstract

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