TY - JOUR
T1 - A random model for mapping imprinted quantitative trait loci in a structured pedigree
T2 - An implication for mapping canine hip dysplasia
AU - Liu, Tian
AU - Todhunter, Rory J.
AU - Wu, Song
AU - Hou, Wei
AU - Mateescu, Raluca
AU - Zhang, Zhiwu
AU - Burton-Wurster, Nancy I.
AU - Acland, Gregory M.
AU - Lust, George
AU - Wu, Rongling
N1 - Funding Information:
The preparation of the manuscript was supported by a grant from the Morris Animal Foundation; NIH AR36554; the Consolidated Research Grant Program; the Cornell Advanced Technology, Biotechnology Program; Nestle Purina, Inc.; NALBI Mammalian Genotyping Service; Marshfield Medical Research Foundation, Marshfield, WI; Cornell University College of Veterinary Medicine Unrestricted Alumni Funds; and NSF 0540745.
PY - 2007/8
Y1 - 2007/8
N2 - Genetic imprinting may have played a more notable role in shaping embryonic development of plants, animals, and humans than previously appreciated. Quantitative trait loci that are imprinted (iQTL) exert monoallelic effects, depending on the parent of origin, which is an exception to the laws of Mendelian genetics. In this article, we present a modified random effect-based mapping model to use in a genome-wide scan for the distribution of iQTL that contribute to genetic variance for a complex trait in a structured pedigree. This model, implemented with the maximum likelihood method, capitalizes on a network of relatedness for maternally and paternally derived alleles through identical-by-descent sharing, thus allowing for the discrimination of the genetic variances due to alleles derived from maternal and paternal parents. The model was employed to map iQTL responsible for canine hip dysplasia in a multihierarchical canine pedigree, founded with seven greyhounds and six Labrador retrievers. Of eight significant QTL detected, three, located on CFA1, CFA8, and CF28, were found to trigger significant parent-of-origin effects on the age of femoral capital ossification measured at the left and right hips of a canine. The detected iQTL provide important candidate regions for fine-mapping of imprinted genes and for studying their structure and function in the control of complex traits.
AB - Genetic imprinting may have played a more notable role in shaping embryonic development of plants, animals, and humans than previously appreciated. Quantitative trait loci that are imprinted (iQTL) exert monoallelic effects, depending on the parent of origin, which is an exception to the laws of Mendelian genetics. In this article, we present a modified random effect-based mapping model to use in a genome-wide scan for the distribution of iQTL that contribute to genetic variance for a complex trait in a structured pedigree. This model, implemented with the maximum likelihood method, capitalizes on a network of relatedness for maternally and paternally derived alleles through identical-by-descent sharing, thus allowing for the discrimination of the genetic variances due to alleles derived from maternal and paternal parents. The model was employed to map iQTL responsible for canine hip dysplasia in a multihierarchical canine pedigree, founded with seven greyhounds and six Labrador retrievers. Of eight significant QTL detected, three, located on CFA1, CFA8, and CF28, were found to trigger significant parent-of-origin effects on the age of femoral capital ossification measured at the left and right hips of a canine. The detected iQTL provide important candidate regions for fine-mapping of imprinted genes and for studying their structure and function in the control of complex traits.
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U2 - 10.1016/j.ygeno.2007.04.004
DO - 10.1016/j.ygeno.2007.04.004
M3 - Article
C2 - 17531439
AN - SCOPUS:34447107674
SN - 0888-7543
VL - 90
SP - 276
EP - 284
JO - Genomics
JF - Genomics
IS - 2
ER -