A randomized comparison of the methods of sperm preparation for intrauterine insemination

William C. Dodson, Janis Moessner, Jeri Miller, Richard S. Legro, Carol L. Gnatuk

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective: To compare the effectiveness of three methods of sperm preparation for IUI during superovulation of infertile women Design: Randomized assignment of one of three sperm preparation methods. Setting: University infertility practice. Patient(s): Infertile couples undergoing superovulation and IUI. Intervention(s): The method of preparation of sperm for IUI during superovulation was assigned randomly to double centrifugation, multiple-tube swim-up, or Percoll density gradient. Main Outcome Measure(s): Total number and percent recovery of motile sperm, percent of recovered sperm with normal morphology, and cycle fecundity Result(s): No method of sperm preparation provided better cycle fecundity than the others despite differences in sperm recovery. Conclusion(s): Double centrifugation, multiple-tube swim-up, and Percoll density gradient sperm preparation for IUI yield similar cycle fecundity rates.

Original languageEnglish (US)
Pages (from-to)574-575
Number of pages2
JournalFertility and sterility
Issue number3
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology


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