A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum

W. J. Hurst; I. S. Zagon; H. Y. Aboul-Enein

A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum

W. J. Hurst
, I. S. Zagon
, H. Y. Aboul-Enein

Research output: Contribution to journal › Article › peer-review

Abstract

HPLC with UV and electrochemical detection has routinely been employed for the determination of the opioid antagonist naltrexone in serum. Sample preparation protocols range from liquid/liquid to solid phase extraction. The sample preparation described in this communication uses ultrafiltration as the mode of sample preparation prior to HPLC analysis. The method is accurate, precise and saves considerable time compared to previously published techniques.

Original language	English (US)
Pages (from-to)	595-596
Number of pages	2
Journal	Pharmazie
Volume	54
Issue number	8
State	Published - 1999

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Cite this

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title = "A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum",

abstract = "HPLC with UV and electrochemical detection has routinely been employed for the determination of the opioid antagonist naltrexone in serum. Sample preparation protocols range from liquid/liquid to solid phase extraction. The sample preparation described in this communication uses ultrafiltration as the mode of sample preparation prior to HPLC analysis. The method is accurate, precise and saves considerable time compared to previously published techniques.",

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N2 - HPLC with UV and electrochemical detection has routinely been employed for the determination of the opioid antagonist naltrexone in serum. Sample preparation protocols range from liquid/liquid to solid phase extraction. The sample preparation described in this communication uses ultrafiltration as the mode of sample preparation prior to HPLC analysis. The method is accurate, precise and saves considerable time compared to previously published techniques.

AB - HPLC with UV and electrochemical detection has routinely been employed for the determination of the opioid antagonist naltrexone in serum. Sample preparation protocols range from liquid/liquid to solid phase extraction. The sample preparation described in this communication uses ultrafiltration as the mode of sample preparation prior to HPLC analysis. The method is accurate, precise and saves considerable time compared to previously published techniques.

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EP - 596

JO - Pharmazie

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IS - 8

ER -

A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum

Abstract

All Science Journal Classification (ASJC) codes

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