TY - JOUR
T1 - A refined treatment strategy for skull base chordoma
T2 - A protocol and management algorithm
AU - Gersey, Zachary C.
AU - Abou-Al-Shaar, Hussam
AU - Cabral, David T.Fernandes
AU - Alattar, Ali A.
AU - Abdallah, Hussein M.
AU - McDowell, Michael M.
AU - Wang, Eric W.
AU - Snyderman, Carl H.
AU - Choby, Garret
AU - Gardner, Paul A.
AU - Zenonos, Georgios A.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Skull base chordomas (SBCs) are rare and challenging tumors due to their midline location and invasive behavior, requiring a multidisciplinary approach that integrates advancements in surgical techniques, radiation therapy, and emerging therapies. This paper synthesizes clinical experience with 307 surgical resections performed on 197 patients to propose a cohesive treatment paradigm for SBCs. The endoscopic endonasal approach (EEA) is highlighted as a cornerstone of surgical management, with key considerations for postoperative radiation strategies and novel therapeutic options, such as immunotherapy, discussed. By emphasizing the importance of maximal safe resection, individualized treatment planning, and ongoing innovation, this paper aims to provide a framework for optimizing outcomes in patients with SBCs while highlighting areas for future research in this complex field.
AB - Skull base chordomas (SBCs) are rare and challenging tumors due to their midline location and invasive behavior, requiring a multidisciplinary approach that integrates advancements in surgical techniques, radiation therapy, and emerging therapies. This paper synthesizes clinical experience with 307 surgical resections performed on 197 patients to propose a cohesive treatment paradigm for SBCs. The endoscopic endonasal approach (EEA) is highlighted as a cornerstone of surgical management, with key considerations for postoperative radiation strategies and novel therapeutic options, such as immunotherapy, discussed. By emphasizing the importance of maximal safe resection, individualized treatment planning, and ongoing innovation, this paper aims to provide a framework for optimizing outcomes in patients with SBCs while highlighting areas for future research in this complex field.
UR - https://www.scopus.com/pages/publications/105019492437
UR - https://www.scopus.com/pages/publications/105019492437#tab=citedBy
U2 - 10.1007/s10143-025-03869-4
DO - 10.1007/s10143-025-03869-4
M3 - Review article
C2 - 41125900
AN - SCOPUS:105019492437
SN - 0344-5607
VL - 48
JO - Neurosurgical Review
JF - Neurosurgical Review
IS - 1
M1 - 729
ER -