A review of cancer in U.S. Hispanic populations

Robert W. Haile, Esther M. John, A. Joan Levine, Victoria K. Cortessis, Jennifer B. Unger, Melissa Gonzales, Elad Ziv, Patricia Thompson, Donna Spruijt-Metz, Katherine L. Tucker, Jonine L. Bernstein, Thomas E. Rohan, Gloria Y.F. Ho, Melissa L. Bondy, Maria Elena Martinez, Linda Cook, Mariana C. Stern, Marcia Cruz Correa, Jonelle Wright, Seth J. SchwartzLourdes Baezconde-Garbanati, Victoria Blinder, Patricia Miranda, Richard Hayes, George Friedman-Jiménez, Kristine R. Monroe, Christopher A. Haiman, Brian E. Henderson, Duncan C. Thomas, Paolo Boffetta

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


There are compelling reasons to conduct studies of cancer in Hispanics, the fastest growing major demographic group in the United States (from 15% to 30% of the U.S. population by 2050). The genetically admixed Hispanic population coupled with secular trends in environmental exposures and lifestyle/ behavioral practices that are associated with immigration and acculturation offer opportunities for elucidating the effects of genetics, environment, and lifestyle on cancer risk and identifying novel risk factors. For example, traditional breast cancer risk factors explain less of the breast cancer risk in Hispanics than in non-Hispanic whites (NHW), and there is a substantially greater proportion of never-smokers with lung cancer in Hispanics than in NHW. Hispanics have higher incidence rates for cancers of the cervix, stomach, liver, and gall bladder than NHW. With respect to these cancers, there are intriguing patterns that warrant study (e.g., depending on country of origin, the five-fold difference in gastric cancer rates for Hispanic men but not Hispanic women). Also, despite a substantially higher incidence rate and increasing secular trend for liver cancer in Hispanics, there have been no studies of Hispanics reported to date. We review the literature and discuss study design options and features that should be considered in future studies.

Original languageEnglish (US)
Pages (from-to)150-163
Number of pages14
JournalCancer Prevention Research
Issue number2
StatePublished - Feb 2012

All Science Journal Classification (ASJC) codes

  • General Medicine


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