TY - JOUR
T1 - A Review of Select Centralized Pain Syndromes
T2 - Relationship With Childhood Sexual Abuse, Opiate Prescribing, and Treatment Implications for the Primary Care Physician
AU - Spiegel, David R.
AU - Chatterjee, Aparna
AU - McCroskey, Aidan L.
AU - Ahmadi, Tamana
AU - Simmelink, Drew
AU - Oldfield, Edward C.
AU - Pryor, Christopher R.
AU - Faschan, Michael
AU - Raulli, Olivia
N1 - Publisher Copyright:
© The Author(s) 2015.
PY - 2015
Y1 - 2015
N2 - Pain can be broadly divided into 3 classes, including nociceptive or inflammatory pain (protective), neuropathic (pathological, occurring after damage to the nervous system), or centralized (pathological, due to abnormal function but with no damage or inflammation to the nervous system). The latter has been posited to occur when descending analgesic pathways are attenuated and/or glutamatergic transmission is facilitated. Additionally, this “pain prone phenotype” can be associated with early life trauma and a suboptimal response to opiates. This article will review the relationships between centralized pain syndromes (ie, fibromyalgia, chronic low back pain), childhood sexual abuse, and opiate misuse. Finally, treatment implications, potentially effecting primary care physicians, will be discussed.
AB - Pain can be broadly divided into 3 classes, including nociceptive or inflammatory pain (protective), neuropathic (pathological, occurring after damage to the nervous system), or centralized (pathological, due to abnormal function but with no damage or inflammation to the nervous system). The latter has been posited to occur when descending analgesic pathways are attenuated and/or glutamatergic transmission is facilitated. Additionally, this “pain prone phenotype” can be associated with early life trauma and a suboptimal response to opiates. This article will review the relationships between centralized pain syndromes (ie, fibromyalgia, chronic low back pain), childhood sexual abuse, and opiate misuse. Finally, treatment implications, potentially effecting primary care physicians, will be discussed.
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U2 - 10.1177/2333392814567920
DO - 10.1177/2333392814567920
M3 - Review article
AN - SCOPUS:85047661070
SN - 2333-3928
VL - 2
JO - Health Services Research and Managerial Epidemiology
JF - Health Services Research and Managerial Epidemiology
ER -