A robust thermal modulator for comprehensive two-dimensional gas chromatography

John B. Phillips; Richard B. Gaines; Jan Blomberg; Frans W.M. Van Der Wielen; Jean Marie Dimandja; Vaughn Green; James Granger; Don Patterson; Laell Racovalis; Henk Jan De Geus; Jacob De Boer; Peter Haglund; John Lipsky; Veena Sinha; Edward B. Ledford

doi:10.1002/(SICI)1521-4168(19990101)22:1<3::AID-JHRC3>3.0.CO;2-U

A robust thermal modulator for comprehensive two-dimensional gas chromatography

John B. Phillips, Richard B. Gaines, Jan Blomberg, Frans W.M. Van Der Wielen, Jean Marie Dimandja, Vaughn Green, James Granger, Don Patterson, Laell Racovalis, Henk Jan De Geus, Jacob De Boer, Peter Haglund, John Lipsky, Veena Sinha, Edward B. Ledford

Forensic Science Program

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175 Scopus citations

Abstract

In comprehensive two dimensional gas chromatography (GCxGC), two capillary columns are connected in series through an interface known as a 'thermal modulator'. This device transforms effluent from the first capillary column into a series of sharp injection-like chemical pulses suitable for high-speed chromatography the second column. Dramatic increases in the resolving power, sensitivity, and speed of the gas chromatograph result. This paper describes the development of a robust and reliable thermal modulator for GC x GC.

Original language	English (US)
Pages (from-to)	3-10
Number of pages	8
Journal	HRC Journal of High Resolution Chromatography
Volume	22
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1521-4168(19990101)22:1<3::AID-JHRC3>3.0.CO;2-U
State	Published - 1999

All Science Journal Classification (ASJC) codes

General Chemical Engineering

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10.1002/(SICI)1521-4168(19990101)22:1<3::AID-JHRC3>3.0.CO;2-U

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Phillips, J. B., Gaines, R. B., Blomberg, J., Van Der Wielen, F. W. M., Dimandja, J. M., Green, V., Granger, J., Patterson, D., Racovalis, L., De Geus, H. J., De Boer, J., Haglund, P., Lipsky, J., Sinha, V., & Ledford, E. B. (1999). A robust thermal modulator for comprehensive two-dimensional gas chromatography. HRC Journal of High Resolution Chromatography, 22(1), 3-10. https://doi.org/10.1002/(SICI)1521-4168(19990101)22:1<3::AID-JHRC3>3.0.CO;2-U

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title = "A robust thermal modulator for comprehensive two-dimensional gas chromatography",

abstract = "In comprehensive two dimensional gas chromatography (GCxGC), two capillary columns are connected in series through an interface known as a 'thermal modulator'. This device transforms effluent from the first capillary column into a series of sharp injection-like chemical pulses suitable for high-speed chromatography the second column. Dramatic increases in the resolving power, sensitivity, and speed of the gas chromatograph result. This paper describes the development of a robust and reliable thermal modulator for GC x GC.",

author = "Phillips, \{John B.\} and Gaines, \{Richard B.\} and Jan Blomberg and \{Van Der Wielen\}, \{Frans W.M.\} and Dimandja, \{Jean Marie\} and Vaughn Green and James Granger and Don Patterson and Laell Racovalis and \{De Geus\}, \{Henk Jan\} and \{De Boer\}, Jacob and Peter Haglund and John Lipsky and Veena Sinha and Ledford, \{Edward B.\}",

year = "1999",

doi = "10.1002/(SICI)1521-4168(19990101)22:1<3::AID-JHRC3>3.0.CO;2-U",

language = "English (US)",

volume = "22",

pages = "3--10",

journal = "HRC Journal of High Resolution Chromatography",

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publisher = "John Wiley and Sons Inc.",

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Phillips, JB, Gaines, RB, Blomberg, J, Van Der Wielen, FWM, Dimandja, JM, Green, V, Granger, J, Patterson, D, Racovalis, L, De Geus, HJ, De Boer, J, Haglund, P, Lipsky, J, Sinha, V & Ledford, EB 1999, 'A robust thermal modulator for comprehensive two-dimensional gas chromatography', HRC Journal of High Resolution Chromatography, vol. 22, no. 1, pp. 3-10. https://doi.org/10.1002/(SICI)1521-4168(19990101)22:1<3::AID-JHRC3>3.0.CO;2-U

TY - JOUR

T1 - A robust thermal modulator for comprehensive two-dimensional gas chromatography

AU - Phillips, John B.

AU - Gaines, Richard B.

AU - Blomberg, Jan

AU - Van Der Wielen, Frans W.M.

AU - Dimandja, Jean Marie

AU - Green, Vaughn

AU - Granger, James

AU - Patterson, Don

AU - Racovalis, Laell

AU - De Geus, Henk Jan

AU - De Boer, Jacob

AU - Haglund, Peter

AU - Lipsky, John

AU - Sinha, Veena

AU - Ledford, Edward B.

PY - 1999

Y1 - 1999

N2 - In comprehensive two dimensional gas chromatography (GCxGC), two capillary columns are connected in series through an interface known as a 'thermal modulator'. This device transforms effluent from the first capillary column into a series of sharp injection-like chemical pulses suitable for high-speed chromatography the second column. Dramatic increases in the resolving power, sensitivity, and speed of the gas chromatograph result. This paper describes the development of a robust and reliable thermal modulator for GC x GC.

AB - In comprehensive two dimensional gas chromatography (GCxGC), two capillary columns are connected in series through an interface known as a 'thermal modulator'. This device transforms effluent from the first capillary column into a series of sharp injection-like chemical pulses suitable for high-speed chromatography the second column. Dramatic increases in the resolving power, sensitivity, and speed of the gas chromatograph result. This paper describes the development of a robust and reliable thermal modulator for GC x GC.

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M3 - Article

AN - SCOPUS:0032948757

SN - 0935-6304

VL - 22

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JO - HRC Journal of High Resolution Chromatography

JF - HRC Journal of High Resolution Chromatography

IS - 1

ER -

A robust thermal modulator for comprehensive two-dimensional gas chromatography

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