A safety review of long-acting β2-agonists in patients with asthma

Nicholas L. Rider, Timothy J. Craig

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Inhaled corticosteroids are the mainstay of asthma therapy; however, inhaled long-acting β2-agonists (LABAs) are frequently used in the treatment of patients with asthma. LABAs are combined with high-dose inhaled corticosteroids (ICSs) for patients with severe persistent asthma, and they are combined with low-dose ICSs for patients older than 5 years with moderate persistent asthma. Recent safety concerns raised by data from the Salmeterol Multi-Center Research Trial (SMART) have indicated that use of LABAs in some populations may contribute to increased mortality. These concerns are warranted when LABAs are used as monotherapy in the treatment of patients with asthma in whom they may cause increased exacerbations, blunting of rescue-medication effect, and worsening symptoms. However, when used in combination with an ICS, they decrease both rescue-medication use and symptoms, increase lung function, and act as steroid-sparing agents.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalJournal of the American Osteopathic Association
Issue number9
StatePublished - Sep 1 2006

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine


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