A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene

David J. Vandenbergh; Michael D. Grant; Virginia Severns

doi:10.1016/j.mcp.2003.07.003

A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene

David J. Vandenbergh, Michael D. Grant, Virginia Severns

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3 Scopus citations

Abstract

The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine- transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.

Original language	English (US)
Pages (from-to)	319-320
Number of pages	2
Journal	Molecular and Cellular Probes
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.mcp.2003.07.003
State	Published - Dec 2003

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1016/j.mcp.2003.07.003

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@article{a83c1720a2d648bc9c2a9d271e533ae1,

title = "A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene",

abstract = "The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine- transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.",

author = "Vandenbergh, {David J.} and Grant, {Michael D.} and Virginia Severns",

note = "Funding Information: The authors would like to thank Jeanne Spicer for assistance with SAS. We also thank Jon Katze, Richard J. O'Connor, Lynn Kozlowski and George Vogler for discussions and support. This work was supported by a grant from the National Cancer Institute (CA81639). This project was also funded, in part, under a grant with the Pennsylvania Department of Health to D.J.V. The Department specifically disclaims responsibility for any analyses, interpretations or conclusions.",

year = "2003",

month = dec,

doi = "10.1016/j.mcp.2003.07.003",

language = "English (US)",

volume = "17",

pages = "319--320",

journal = "Molecular and Cellular Probes",

issn = "0890-8508",

publisher = "Academic Press Inc.",

number = "6",

}

TY - JOUR

T1 - A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene

AU - Vandenbergh, David J.

AU - Grant, Michael D.

AU - Severns, Virginia

N1 - Funding Information: The authors would like to thank Jeanne Spicer for assistance with SAS. We also thank Jon Katze, Richard J. O'Connor, Lynn Kozlowski and George Vogler for discussions and support. This work was supported by a grant from the National Cancer Institute (CA81639). This project was also funded, in part, under a grant with the Pennsylvania Department of Health to D.J.V. The Department specifically disclaims responsibility for any analyses, interpretations or conclusions.

PY - 2003/12

Y1 - 2003/12

N2 - The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine- transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.

AB - The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine- transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.

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DO - 10.1016/j.mcp.2003.07.003

M3 - Article

C2 - 14602484

AN - SCOPUS:0242320538

SN - 0890-8508

VL - 17

SP - 319

EP - 320

JO - Molecular and Cellular Probes

JF - Molecular and Cellular Probes

IS - 6

ER -

A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene

Abstract

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