A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Atanu Duttaroy; Anirban Paul; Mukta Kundu; Amy Belton

A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Atanu Duttaroy, Anirban Paul, Mukta Kundu, Amy Belton

Research output: Contribution to journal › Article › peer-review

Abstract

A null mutation for the Sod2 gene, Sod2ⁿ²⁸³ was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodⁿ²⁸³/Sod ⁿ²⁸³) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2^-/- progeny suffer neonatal lethality. Sod^n283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

Original language	English (US)
Pages (from-to)	2295-2299
Number of pages	5
Journal	Genetics
Volume	165
Issue number	4
State	Published - Dec 2003

All Science Journal Classification (ASJC) codes

Genetics

Cite this

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title = "A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila",

abstract = "A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.",

author = "Atanu Duttaroy and Anirban Paul and Mukta Kundu and Amy Belton",

year = "2003",

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language = "English (US)",

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AU - Belton, Amy

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N2 - A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

AB - A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

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A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Abstract

All Science Journal Classification (ASJC) codes

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