A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Atanu Duttaroy; Anirban Paul; Mukta Kundu; Amy Belton

A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Atanu Duttaroy
, Anirban Paul
, Mukta Kundu
, Amy Belton

Research output: Contribution to journal › Article › peer-review

Abstract

A null mutation for the Sod2 gene, Sod2ⁿ²⁸³ was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodⁿ²⁸³/Sod ⁿ²⁸³) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2^-/- progeny suffer neonatal lethality. Sod^n283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

Original language	English (US)
Pages (from-to)	2295-2299
Number of pages	5
Journal	Genetics
Volume	165
Issue number	4
State	Published - Dec 2003

All Science Journal Classification (ASJC) codes

Genetics

Cite this

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title = "A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila",

abstract = "A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.",

author = "Atanu Duttaroy and Anirban Paul and Mukta Kundu and Amy Belton",

year = "2003",

month = dec,

language = "English (US)",

volume = "165",

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journal = "Genetics",

issn = "0016-6731",

publisher = "Oxford University Press",

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AU - Duttaroy, Atanu

AU - Paul, Anirban

AU - Kundu, Mukta

AU - Belton, Amy

PY - 2003/12

Y1 - 2003/12

N2 - A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

AB - A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

UR - https://www.scopus.com/pages/publications/0346100684

UR - https://www.scopus.com/pages/publications/0346100684#tab=citedBy

M3 - Article

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AN - SCOPUS:0346100684

SN - 0016-6731

VL - 165

SP - 2295

EP - 2299

JO - Genetics

JF - Genetics

IS - 4

ER -

A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Abstract

All Science Journal Classification (ASJC) codes

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