A statistical framework for recovering pseudo-dynamic networks from static data

Chixiang Chen, Biyi Shen, Tianzhou Ma, Ming Wang, Rongling Wu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Motivation: The collection of temporal or perturbed data is often a prerequisite for reconstructing dynamic networks in most cases. However, these types of data are seldom available for genomic studies in medicine, thus significantly limiting the use of dynamic networks to characterize the biological principles underlying human health and diseases. Results: We proposed a statistical framework to recover disease risk-associated pseudo-dynamic networks (DRDNet) from steady-state data. We incorporated a varying coefficient model with multiple ordinary differential equations to learn a series of networks. We analyzed the publicly available Genotype-Tissue Expression data to construct networks associated with hypertension risk, and biological findings showed that key genes constituting these networks had pivotal and biologically relevant roles associated with the vascular system. We also provided the selection consistency of the proposed learning procedure and evaluated its utility through extensive simulations.

Original languageEnglish (US)
Pages (from-to)2481-2487
Number of pages7
JournalBioinformatics
Volume38
Issue number9
DOIs
StatePublished - May 1 2022

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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