A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

E. L. Tolman; L. E. Metzger; L. S. Jefferson

doi:10.1016/0006-291X(70)90502-4

A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

E. L. Tolman, L. E. Metzger, L. S. Jefferson

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Abstract

Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of ¹⁴C-alanine and ¹⁴C-lactate to glucose were observed in livers of these rats.

Original language	English (US)
Pages (from-to)	294-298
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(70)90502-4
State	Published - Oct 23 1970

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(70)90502-4

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abstract = "Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.",

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AU - Metzger, L. E.

AU - Jefferson, L. S.

PY - 1970/10/23

Y1 - 1970/10/23

N2 - Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.

AB - Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.

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IS - 2

ER -

A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

Abstract

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