TY - JOUR
T1 - A structural perspective on the where, how, why, and what of nucleosome positioning
AU - Arya, Gaurav
AU - Maitra, Arijit
AU - Grigoryev, Sergei A.
N1 - Funding Information:
This work was supported by Hellman Fellowship to G. Arya and NSF grant MCB-0615536 to S. Grigoryev.
PY - 2010/6
Y1 - 2010/6
N2 - The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.
AB - The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.
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U2 - 10.1080/07391102.2010.10508585
DO - 10.1080/07391102.2010.10508585
M3 - Article
C2 - 20232935
AN - SCOPUS:77953305748
SN - 0739-1102
VL - 27
SP - 803
EP - 820
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
IS - 6
ER -