A study of new fragrance mixtures

Walter Larsen, Hideo Nakayama, Torkel Fischer, Peter Elsner, Peter Frosch, Desmond Burrows, William Jordan, Stephanie Shaw, John Wilkinson, James Marks, M. Sugawara, Marc Nethercott, James Nethercottt

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Objective: To determine the frequency of responses to four mixtures of fragrance materials in routine clinic patients undergoing patch testing for suspect allergic contact dermatitis. The validity of using fragrance: mixtures alone, or in combination, was evaluated in terms of predicting allergy to fragrance judged on the basis of finding a response to at least one of the fragrance mixtures. Methods: A total of 752 subjects were patch tested in five centers worldwide with (1) fragrance mix 8% (FM), (2) balsam of Peru 25%, (3) a mixture of seven of the eight FM 8% ingredients and other fragrance ingredients including jasmine absolute (jasmine/FM mix), and (4) a mixture of five selected natural fragrance ingredients (NM). Results: Of 752 subjects, 100 (13%) had positive patch tests to at least one of the four fragrance mixtures. The age of the patients was 45.2 ± 18.3 years (mean ±SDL Ninety-six percent were Caucasian. Facial eruptions and hand involvement were the most common topographic sites. Of subjects exhibiting a positive response, 67% reacted to FM, 63% to the jasmine/FM mix, 47% to the NM, and 38% to balsam of Peru. Testing with FM and NM identified 84% of the perfume-allergic patients. FM 8% tested simultaneously with the jasmine/FM mix identified 86% of the perfume-allergic patients. Testing simultaneously with three test materials combining either the NM or the jasmine/FM mix with balsam of Peru and FM identified 95% of the perfume-sensitive patients. Conclusions: The simultaneous testing of NM or jasmine/FM mix, in addition to the conventional use of FM 8% and balsam of Peru, increases the sensitivity of testing for fragrance allergy from 81% to 95%.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalUnknown Journal
Issue number4
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Dermatology


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