A surveillance conundrum: A case of 4 distinct primary malignancies in a BRCA-1 mutation carrier

Stephanie Ricci, Aaron Shafer, Stacy Nerenstone, Srini Mandavilli, Joel Sorosky

Research output: Contribution to journalArticlepeer-review


Women with HBOC syndrome present a unique challenge to the oncology community, as will many genetic cancer syndromes yet to be discovered as genetic testing increases in availability. Issues of management and, most importantly, implication are yet to be elucidated. After a diagnosis of epithelial ovarian carcinoma lifelong follow-up is recommended. Given the high recurrence rate and dismal long term prognosis of advanced epithelial ovarian carcinoma this recommendation is more often than not moot. There are no clear guidelines or recommendations for surveillance designed for women with disease free survival greater than five years. This case presents a unique scenario of a woman with predictable disease that remains unpreventable.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalInternational Journal of Gynecological Pathology
Issue number2
StatePublished - Mar 2012

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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