A synthetic equivalent for ortho-lithio-n-methylaniline

Joseph Sisko, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


o-Bromo-N-methyl-N-n-propoxyaniline undergoes halogen-metal exchange with butyllithium and the resulting lithio species reacts cleanly with a variety of electrophiles. The N-0 bond of these products can be reduced with Raney nickel to afford ortho-substituted-N-methylanilines.

Original languageEnglish (US)
Pages (from-to)1035-1041
Number of pages7
JournalSynthetic Communications
Issue number10
StatePublished - Jul 1 1988

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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