A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality

Chiara Sartini, Vladimir Lomivorotov, Marina Pieri, Juan Carlos Lopez-Delgado, Martina Baiardo Redaelli, Ludhmila Hajjar, Antonio Pisano, Valery Likhvantsev, Evgeny Fominskiy, Nikola Bradic, Luca Cabrini, Maxim Novikov, Daniele Avancini, Hynek Riha, Rosalba Lembo, Gordana Gazivoda, Gianluca Paternoster, Chengbin Wang, Simona Tamà, Gabriele AlvaroChew Yin Wang, Agostino Roasio, Laura Ruggeri, Chow Yen Yong, Daniela Pasero, Luca Severi, Laura Pasin, Giuseppe Mancino, Paolo Mura, Mario Musu, Savino Spadaro, Massimiliano Conte, Rosetta Lobreglio, Simona Silvetti, Carmine Domenico Votta, Alessandro Belletti, Diana Di Fraja, Francesco Corradi, Claudia Brusasco, Emanuela Saporito, Alessandro D'Amico, Salvatore Sardo, Alessandro Ortalda, Claudio Riefolo, Fabrizio Monaco, Alberto Zangrillo, Rinaldo Bellomo, Giovanni Landoni

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The authors aimed to identify interventions documented by randomized controlled trials (RCTs) that reduce mortality in adult critically ill and perioperative patients, followed by a survey of clinicians’ opinions and routine practices to understand the clinicians’ response to such evidence. The authors performed a comprehensive literature review to identify all topics reported to reduce mortality in perioperative and critical care settings according to at least 2 RCTs or to a multicenter RCT or to a single-center RCT plus guidelines. The authors generated position statements that were voted on online by physicians worldwide for agreement, use, and willingness to include in international guidelines. From 262 RCT manuscripts reporting mortality differences in the perioperative and critically ill settings, the authors selected 27 drugs, techniques, and strategies (66 RCTs, most frequently published by the New England Journal of Medicine [13 papers], Lancet [7], and Journal of the American Medical Association [5]) with an agreement ≥67% from over 250 physicians (46 countries). Noninvasive ventilation was the intervention supported by the largest number of RCTs (n = 13). The concordance between agreement and use (a positive answer both to “do you agree” and “do you use”) showed differences between Western and other countries and between anesthesiologists and intensive care unit physicians. The authors identified 27 clinical interventions with randomized evidence of survival benefit and strong clinician support in support of their potential life-saving properties in perioperative and critically ill patients with noninvasive ventilation having the highest level of support. However, clinician views appear affected by specialty and geographical location.

Original languageEnglish (US)
Pages (from-to)1430-1439
Number of pages10
JournalJournal of cardiothoracic and vascular anesthesia
Issue number5
StatePublished - May 1 2019

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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