A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging

Haoyang Chen, Sumit Agrawal, Mohamed Osman, Josiah Minotto, Shubham Mirg, Jinyun Liu, Ajay Dangi, Quyen Tran, Thomas Jackson, Sri Rajasekhar Kothapalli

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objective and Impact Statement. Simultaneous imaging of ultrasound and optical contrasts can help map structural, functional, and molecular biomarkers inside living subjects with high spatial resolution. There is a need to develop a platform to facilitate this multimodal imaging capability to improve diagnostic sensitivity and specificity. Introduction. Currently, combining ultrasound, photoacoustic, and optical imaging modalities is challenging because conventional ultrasound transducer arrays are optically opaque. As a result, complex geometries are used to coalign both optical and ultrasound waves in the same field of view. Methods. One elegant solution is to make the ultrasound transducer transparent to light. Here, we demonstrate a novel transparent ultrasound transducer (TUT) linear array fabricated using a transparent lithium niobate piezoelectric material for real-time multimodal imaging. Results. The TUT-array consists of 64 elements and centered at ~6 MHz frequency. We demonstrate a quad-mode ultrasound, Doppler ultrasound, photoacoustic, and fluorescence imaging in real-time using the TUT-array directly coupled to the tissue mimicking phantoms. Conclusion. The TUT-array successfully showed a multimodal imaging capability and has potential applications in diagnosing cancer, neurological, and vascular diseases, including image-guided endoscopy and wearable imaging.

Original languageEnglish (US)
Article number9871098
JournalBME Frontiers
Volume2022
DOIs
StatePublished - Jan 2022

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Medicine (miscellaneous)

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