A triggered DNA hydrogel cover to envelop and release single cells

Juan Jin; Yongzheng Xing; Yanli Xi; Xueli Liu; Tao Zhou; Xinxin Ma; Zhongqiang Yang; Shutao Wang; Dongsheng Liu

doi:10.1002/adma.201301175

A triggered DNA hydrogel cover to envelop and release single cells

Juan Jin, Yongzheng Xing, Yanli Xi, Xueli Liu, Tao Zhou, Xinxin Ma, Zhongqiang Yang, Shutao Wang, Dongsheng Liu

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.

Original language	English (US)
Pages (from-to)	4714-4717
Number of pages	4
Journal	Advanced Materials
Volume	25
Issue number	34
DOIs	https://doi.org/10.1002/adma.201301175
State	Published - Sep 14 2013

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201301175

Cite this

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abstract = "We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.",

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AU - Jin, Juan

AU - Xing, Yongzheng

AU - Xi, Yanli

AU - Liu, Xueli

AU - Zhou, Tao

AU - Ma, Xinxin

AU - Yang, Zhongqiang

AU - Wang, Shutao

AU - Liu, Dongsheng

PY - 2013/9/14

Y1 - 2013/9/14

N2 - We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.

AB - We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.

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JO - Advanced Materials

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ER -

A triggered DNA hydrogel cover to envelop and release single cells

Abstract

All Science Journal Classification (ASJC) codes

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