A triggered DNA hydrogel cover to envelop and release single cells

Juan Jin, Yongzheng Xing, Yanli Xi, Xueli Liu, Tao Zhou, Xinxin Ma, Zhongqiang Yang, Shutao Wang, Dongsheng Liu

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.

Original languageEnglish (US)
Pages (from-to)4714-4717
Number of pages4
JournalAdvanced Materials
Volume25
Issue number34
DOIs
StatePublished - Sep 14 2013

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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