A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker; Scott T. Phillips

doi:10.1021/ja108347d

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker, Scott T. Phillips

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

Original language	English (US)
Pages (from-to)	5170-5173
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	14
DOIs	https://doi.org/10.1021/ja108347d
State	Published - Apr 13 2011

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja108347d

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title = "A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)",

abstract = "A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.",

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AB - A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

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A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Abstract

All Science Journal Classification (ASJC) codes

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