@article{0df7d171455d40f4bc2ba5dd612382d2,
title = "A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium",
abstract = "Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.",
author = "Moreira, {Luciano A.} and I{\~n}aki Iturbe-Ormaetxe and Jeffery, {Jason A.} and Guangjin Lu and Pyke, {Alyssa T.} and Hedges, {Lauren M.} and Rocha, {Bruno C.} and Sonja Hall-Mendelin and Andrew Day and Markus Riegler and Hugo, {Leon E.} and Johnson, {Karyn N.} and Kay, {Brian H.} and McGraw, {Elizabeth A.} and {van den Hurk}, {Andrew F.} and Ryan, {Peter A.} and O'Neill, {Scott L.}",
note = "Funding Information: We are grateful to Nichola Kenny and Wai Yuen Cheah for technical support and Paul Addison and Amy Fong for help with mosquito histology. We are also thankful to Roy Hall and Natalie Prow for providing the anti-dengue and B10 antibodies, Antoniana Krettli for the anti-CSP antibody, and Jos{\'e} Ribeiro for useful discussions on saliva collection. We are particularly thankful for wild caught mosquito material supplied by Petrina Johnson and Scott Ritchie. We would like to thank FIOCRUZ - Brazil for the support on the malaria experiments. We thank members of the O'Neill and McGraw laboratories for critical reading of the manuscript. This research was supported by a grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative of the Bill and Melinda Gates Foundation and the National Health and Medical Research Council, Australia. ",
year = "2009",
month = dec,
day = "24",
doi = "10.1016/j.cell.2009.11.042",
language = "English (US)",
volume = "139",
pages = "1268--1278",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "7",
}
