AACC Guidance Document on Cervical Cancer Detection: Screening, Surveillance, and Diagnosis

Yusheng Zhu, Sarah Feldman, Shuk On Annie Leung, Michael H. Creer, Joshua Warrick, Nicole Williams, Stephen Mastorides

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Persistent genital infection with high-risk human papilloma virus (hrHPV) causes the vast majority of cases of cervical cancer. Early screening, ongoing surveillance, and accurate diagnosis are crucial for the elimination of cervical cancer. New screening guidelines for testing in asymptomatic healthy populations and management guidelines for managing abnormal results have been published by professional organizations. Content: This guidance document addresses key questions related to cervical cancer screening and management including currently available cervical cancer screening tests and the testing strategies for cervical cancer screening. This guidance document introduces the most recently updated screening guidelines regarding age to start screening, age to stop screening, and frequencies of routine screening as well as risk-based management guidelines for screening and surveillance. This guidance document also summarizes the methodologies for the diagnosis of cervical cancer. Additionally, we propose a report template for human papilloma virus (HPV) and cervical cancer detection to facilitate interpretation of results and clinical decision-making. Summary: Currently available cervical cancer screening tests include hrHPV testing and cervical cytology screening. The screening strategies can be primary HPV screening, co-testing with HPV testing and cervical cytology, and cervical cytology alone. The new American Society for Colposcopy and Cervical Pathology guidelines recommend variable frequencies of screening and surveillance based on risk. To implement these guidelines, an ideal laboratory report should include the indication for the test (screening, surveillance, or diagnostic workup of symptomatic patients); type of test (primary HPV screening, co-testing, or cytology alone); clinical history of the patient; and prior as well as current testing results.

Original languageEnglish (US)
Pages (from-to)382-406
Number of pages25
JournalJournal of Applied Laboratory Medicine
Issue number2
StatePublished - Mar 1 2023

All Science Journal Classification (ASJC) codes

  • General Medicine

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