ABC294640, A novel sphingosine kinase 2 inhibitor, induces oncogenic virus–infected cell autophagic death and represses tumor growth

Keyphrases

• Tumor Growth 100%
• ABC294640 100%
• Sphingosine Kinase 2 Inhibitors 100%
• Kaposi Sarcoma 100%
• Herpesvirus 71%
• SphK2 42%
• Ceramide 28%
• Sphingolipid Metabolism 28%
• Malignancy 28%
• Primary Effusion Lymphoma 28%
• Effective Treatment 14%
• Apoptosis 14%
• Uninfected Cells 14%
• Tumor Cells 14%
• Selective Inhibitor 14%
• Sphingosine-1-phosphate 14%
• Induced Apoptosis 14%
• Tumor Growth in Vivo 14%
• Metabolic Processes 14%
• Therapeutic Strategies 14%
• Anti-apoptotic 14%
• Pro-apoptotic 14%
• Transcriptome Analysis 14%
• Etiological Agents 14%
• Virus-associated Cancer 14%
• Early Growth Response Protein 1 (EGR1) 14%
• HIV+ Patients 14%
• Cellular Stress Response 14%
• Endothelial Cell Line 14%
• Primary Endothelial Cells 14%
• LC3B 14%
• Nude Mouse Model 14%

Medicine and Dentistry

• Tumor Progression 100%
• Sphingosine Kinase 2 100%
• Herpesviridae 83%
• Ceramide 33%
• Programmed Cell Death 33%
• Cancer 33%
• Sphingolipid Metabolism 33%
• Endothelial Cell 16%
• Cell Cycle 16%
• Human Immunodeficiency Virus 16%
• Tumor Cell 16%
• Upregulation 16%
• Virus Carcinogenesis 16%
• Antiapoptotic 16%
• Gene Expression Profiling 16%
• Kaposi Sarcoma 16%
• Sphingosine 1 Phosphate 16%
• Endothelial Cell Line 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Tumor Growth 100%
• Opaganib 100%
• Sphingosine Kinase 2 100%
• Herpesviridae 83%
• Ceramide 33%
• Sphingolipid 33%
• Primary Effusion Lymphoma 33%
• Neoplasm 16%
• HIV 16%
• Mouse Model 16%
• Sphingosine 1 Phosphate 16%
• Antiapoptotic 16%
• Nude Mouse 16%
• Kaposi Sarcoma 16%