@article{0e019e313d524e1dbe1672d0b822972d,
title = "Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder",
abstract = "Neuroimaging research has implicated abnormalities in cortico-striatal-thalamic-cortical (CSTC) circuitry in pediatric obsessive-compulsive disorder (OCD). In this study, resting-state functional magnetic resonance imaging (R-fMRI) was used to investigate functional connectivity in the CSTC circuitry in adolescents with OCD. Imaging was obtained with the Human Connectome Project (HCP) scanner using newly developed pulse sequences which allow for higher spatial and temporal resolution. Fifteen adolescents with OCD and 13 age- and gender-matched healthy controls (ages 12-19) underwent R-fMRI on the 3T HCP scanner. Twenty-four minutes of resting-state scans (two consecutive 12-min scans) were acquired. We investigated functional connectivity of the striatum using a seed-based, whole brain approach with anatomically-defined seeds placed in the bilateral caudate, putamen, and nucleus accumbens. Adolescents with OCD compared with controls exhibited significantly lower functional connectivity between the left putamen and a single cluster of right-sided cortical areas including parts of the orbitofrontal cortex, inferior frontal gyrus, insula, and operculum. Preliminary findings suggest that impaired striatal connectivity in adolescents with OCD in part falls within the predicted CSTC network, and also involves impaired connections between a key CSTC network region (i.e., putamen) and key regions in the salience network (i.e., insula/operculum). The relevance of impaired putamen-insula/operculum connectivity in OCD is discussed.",
author = "Bernstein, {Gail A.} and Mueller, {Bryon A.} and Schreiner, {Melinda Westlund} and Campbell, {Sarah M.} and Regan, {Emily K.} and Nelson, {Peter M.} and Houri, {Alaa K.} and Lee, {Susanne S.} and Zagoloff, {Alexandra D.} and Lim, {Kelvin O.} and Yacoub, {Essa S.} and Cullen, {Kathryn R.}",
note = "Funding Information: The authors extend special thanks to the adolescents and their parents who participated in the study. This study was funded by the University of Minnesota Academic Health Center Seed Grant #11.48 and grants from the National Institutes of Health including R21MH101395 (Bernstein), the Human Connectome Project 1U54MH091657, 1P30NS076408, and P41EB015894. The work was carried out in part using computing resources at the University of Minnesota Supercomputing Institute. The funding sponsors had no role in study design; collection, analysis, or interpretation of data; writing the manuscript; or the decision to submit the paper for publication. Presented at the 62nd Annual Meeting of the American Academy of Child and Adolescent Psychiatry in San Antonio, October 2015.All authors report no conflicts of interest. Authors Bernstein, Mueller, and Cullen designed the study. Authors Mueller, Westlund Schreiner, Campbell, Regan, Nelson, and Houri collected the data. Authors Mueller, Westlund Schreiner, Lee, and Cullen conducted the analyses of the data. All authors contributed to the interpretation of the data and discussed content of the paper. Author Bernstein wrote the first draft of the manuscript and all authors contributed to the final manuscript. Funding Information: The authors extend special thanks to the adolescents and their parents who participated in the study. This study was funded by the University of Minnesota Academic Health Center Seed Grant #11.48 and grants from the National Institutes of Health including R21MH101395 (Bernstein), the Human Connectome Project 1U54MH091657 , 1P30NS076408 , and P41EB015894 . The work was carried out in part using computing resources at the University of Minnesota Supercomputing Institute. The funding sponsors had no role in study design; collection, analysis, or interpretation of data; writing the manuscript; or the decision to submit the paper for publication. Presented at the 62nd Annual Meeting of the American Academy of Child and Adolescent Psychiatry in San Antonio, October 2015. Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",
year = "2016",
month = jan,
day = "30",
doi = "10.1016/j.pscychresns.2015.11.002",
language = "English (US)",
volume = "247",
pages = "49--56",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
}
