Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

Christopher J. Earley; J. R. Connor; J. L. Beard; E. A. Malecki; D. K. Epstein; R. P. Allen

doi:10.1212/WNL.54.8.1698

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

Christopher J. Earley, J. R. Connor, J. L. Beard, E. A. Malecki, D. K. Epstein, R. P. Allen

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Abstract

CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 ± 0.25 ng/mL versus 3.50 ± 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 ± 5.1 mg/L versus 6.71 ± 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.

Original language	English (US)
Pages (from-to)	1698-1700
Number of pages	3
Journal	Neurology
Volume	54
Issue number	8
DOIs	https://doi.org/10.1212/WNL.54.8.1698
State	Published - Apr 25 2000

All Science Journal Classification (ASJC) codes

Clinical Neurology

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title = "Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome",

abstract = "CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 ± 0.25 ng/mL versus 3.50 ± 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 ± 5.1 mg/L versus 6.71 ± 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.",

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T1 - Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

AU - Earley, Christopher J.

AU - Connor, J. R.

AU - Beard, J. L.

AU - Malecki, E. A.

AU - Epstein, D. K.

AU - Allen, R. P.

PY - 2000/4/25

Y1 - 2000/4/25

N2 - CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 ± 0.25 ng/mL versus 3.50 ± 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 ± 5.1 mg/L versus 6.71 ± 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.

AB - CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 ± 0.25 ng/mL versus 3.50 ± 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 ± 5.1 mg/L versus 6.71 ± 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.

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Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

Abstract

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