Abstract
The mammalian fetus usually expresses major histocompatibility antigens not present in the mother. Such incompatibility of major histocompatibility antigens between ordinary grafts and the recipient provokes a powerful immune response and rejection of the grafts. Survival of the fetus despite this barrier has been ascribed to a low level of expression of histocompatibility antigens or to maternal immune tolerance or to the existence of a barrier posed by the placenta. Here, we discuss a fourth potential mechanism. The mechanism involves acquired resistance to immune-mediated injury and was originally described in organ transplants found to resist injury by antibodies and complement. The mechanism is called accommodation.
Original language | English (US) |
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Title of host publication | Human Fetal Tissue Transplantation |
Publisher | Springer-Verlag London Ltd |
Pages | 79-85 |
Number of pages | 7 |
Volume | 9781447141716 |
ISBN (Electronic) | 9781447141716 |
ISBN (Print) | 1447141709, 9781447141709 |
DOIs | |
State | Published - Mar 1 2013 |
All Science Journal Classification (ASJC) codes
- General Medicine