Accommodation and the fetus

Ines Silva, Cody A. Koch, Raymond J. Lynch, Jeffrey L. Platt

Research output: Chapter in Book/Report/Conference proceedingChapter


The mammalian fetus usually expresses major histocompatibility antigens not present in the mother. Such incompatibility of major histocompatibility antigens between ordinary grafts and the recipient provokes a powerful immune response and rejection of the grafts. Survival of the fetus despite this barrier has been ascribed to a low level of expression of histocompatibility antigens or to maternal immune tolerance or to the existence of a barrier posed by the placenta. Here, we discuss a fourth potential mechanism. The mechanism involves acquired resistance to immune-mediated injury and was originally described in organ transplants found to resist injury by antibodies and complement. The mechanism is called accommodation.

Original languageEnglish (US)
Title of host publicationHuman Fetal Tissue Transplantation
PublisherSpringer-Verlag London Ltd
Number of pages7
ISBN (Electronic)9781447141716
ISBN (Print)1447141709, 9781447141709
StatePublished - Mar 1 2013

All Science Journal Classification (ASJC) codes

  • General Medicine

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