Acid-Labile Alpha Interferon

Jon A. Green; S. L. Spruance; Jens Roar Bjerke; Gunnar Haukenes; John Karsten Livden; Roald Matre; Miklos Degré; Olivia T. Preble; M. Elaine Eyster; James J. Goedert

doi:10.1056/NEJM198404053101413

Acid-Labile Alpha Interferon

Jon A. Green, S. L. Spruance, Jens Roar Bjerke, Gunnar Haukenes, John Karsten Livden, Roald Matre, Miklos Degré, Olivia T. Preble, M. Elaine Eyster, James J. Goedert

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

To the Editor: In the September 8 issue, Eyster et al. present data suggesting that the presence of serum interferon may be a reliable predictor of incipient acquired immunodeficiency syndrome (AIDS).¹ The prognostic value of serum interferon in persons at risk of AIDS derives from the supposedly unique acid lability of interferon in prodromal AIDS, which distinguishes it from alpha interferon produced in tissue culture. As noted by the authors, relatively acid-labile alpha interferon is also found in the serum of some persons with active AIDS² or systemic lupus erythematosus.³ In these instances the assumption is made that the acid.

Original language	English (US)
Pages (from-to)	922-924
Number of pages	3
Journal	New England Journal of Medicine
Volume	310
Issue number	14
DOIs	https://doi.org/10.1056/NEJM198404053101413
State	Published - Apr 5 1984

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General Medicine

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title = "Acid-Labile Alpha Interferon",

abstract = "To the Editor: In the September 8 issue, Eyster et al. present data suggesting that the presence of serum interferon may be a reliable predictor of incipient acquired immunodeficiency syndrome (AIDS).1 The prognostic value of serum interferon in persons at risk of AIDS derives from the supposedly unique acid lability of interferon in prodromal AIDS, which distinguishes it from alpha interferon produced in tissue culture. As noted by the authors, relatively acid-labile alpha interferon is also found in the serum of some persons with active AIDS2 or systemic lupus erythematosus.3 In these instances the assumption is made that the acid.",

author = "Green, {Jon A.} and Spruance, {S. L.} and Bjerke, {Jens Roar} and Gunnar Haukenes and Livden, {John Karsten} and Roald Matre and Miklos Degr{\'e} and Preble, {Olivia T.} and Eyster, {M. Elaine} and Goedert, {James J.}",

year = "1984",

month = apr,

day = "5",

doi = "10.1056/NEJM198404053101413",

language = "English (US)",

volume = "310",

pages = "922--924",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

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TY - JOUR

T1 - Acid-Labile Alpha Interferon

AU - Green, Jon A.

AU - Spruance, S. L.

AU - Bjerke, Jens Roar

AU - Haukenes, Gunnar

AU - Livden, John Karsten

AU - Matre, Roald

AU - Degré, Miklos

AU - Preble, Olivia T.

AU - Eyster, M. Elaine

AU - Goedert, James J.

PY - 1984/4/5

Y1 - 1984/4/5

N2 - To the Editor: In the September 8 issue, Eyster et al. present data suggesting that the presence of serum interferon may be a reliable predictor of incipient acquired immunodeficiency syndrome (AIDS).1 The prognostic value of serum interferon in persons at risk of AIDS derives from the supposedly unique acid lability of interferon in prodromal AIDS, which distinguishes it from alpha interferon produced in tissue culture. As noted by the authors, relatively acid-labile alpha interferon is also found in the serum of some persons with active AIDS2 or systemic lupus erythematosus.3 In these instances the assumption is made that the acid.

AB - To the Editor: In the September 8 issue, Eyster et al. present data suggesting that the presence of serum interferon may be a reliable predictor of incipient acquired immunodeficiency syndrome (AIDS).1 The prognostic value of serum interferon in persons at risk of AIDS derives from the supposedly unique acid lability of interferon in prodromal AIDS, which distinguishes it from alpha interferon produced in tissue culture. As noted by the authors, relatively acid-labile alpha interferon is also found in the serum of some persons with active AIDS2 or systemic lupus erythematosus.3 In these instances the assumption is made that the acid.

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U2 - 10.1056/NEJM198404053101413

DO - 10.1056/NEJM198404053101413

M3 - Letter

C2 - 6700681

AN - SCOPUS:0021343350

SN - 0028-4793

VL - 310

SP - 922

EP - 924

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 14

ER -

Acid-Labile Alpha Interferon

Abstract

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