Acid-Labile Alpha Interferon

Jon A. Green, S. L. Spruance, Jens Roar Bjerke, Gunnar Haukenes, John Karsten Livden, Roald Matre, Miklos Degré, Olivia T. Preble, M. Elaine Eyster, James J. Goedert

Research output: Contribution to journalLetterpeer-review

5 Scopus citations


To the Editor: In the September 8 issue, Eyster et al. present data suggesting that the presence of serum interferon may be a reliable predictor of incipient acquired immunodeficiency syndrome (AIDS).1 The prognostic value of serum interferon in persons at risk of AIDS derives from the supposedly unique acid lability of interferon in prodromal AIDS, which distinguishes it from alpha interferon produced in tissue culture. As noted by the authors, relatively acid-labile alpha interferon is also found in the serum of some persons with active AIDS2 or systemic lupus erythematosus.3 In these instances the assumption is made that the acid.

Original languageEnglish (US)
Pages (from-to)922-924
Number of pages3
JournalNew England Journal of Medicine
Issue number14
StatePublished - Apr 5 1984

All Science Journal Classification (ASJC) codes

  • General Medicine


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