TY - JOUR
T1 - Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification
AU - Ma, Liqun
AU - Zhang, Xuexin
AU - Zhou, Min
AU - Chen, Haijun
PY - 2012/10/26
Y1 - 2012/10/26
N2 - Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.
AB - Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.
UR - http://www.scopus.com/inward/record.url?scp=84868227336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868227336&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.398164
DO - 10.1074/jbc.M112.398164
M3 - Article
C2 - 22948150
AN - SCOPUS:84868227336
SN - 0021-9258
VL - 287
SP - 37145
EP - 37153
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 44
ER -