Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification

Liqun Ma; Xuexin Zhang; Min Zhou; Haijun Chen

doi:10.1074/jbc.M112.398164

Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification

Liqun Ma
, Xuexin Zhang
, Min Zhou
, Haijun Chen

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background: Two-pore domain K⁺ channels mediate background K⁺ conductance and regulate cellular function. Results: Low extracellular pH (pH_o) significantly increases the Na⁺ to K⁺ relative permeability of TWIK-1, TASK-1, and TASK-3 K⁺ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pH_o. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pH_o.

Original language	English (US)
Pages (from-to)	37145-37153
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.398164
State	Published - Oct 26 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification",

abstract = "Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.",

author = "Liqun Ma and Xuexin Zhang and Min Zhou and Haijun Chen",

year = "2012",

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doi = "10.1074/jbc.M112.398164",

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T1 - Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification

AU - Ma, Liqun

AU - Zhang, Xuexin

AU - Zhou, Min

AU - Chen, Haijun

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.

AB - Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.

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U2 - 10.1074/jbc.M112.398164

DO - 10.1074/jbc.M112.398164

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EP - 37153

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 44

ER -

Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification

Abstract

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