TY - JOUR
T1 - Acoustic propulsion of nanorod motors inside living cells
AU - Wang, Wei
AU - Li, Sixing
AU - Mair, Lamar
AU - Ahmed, Suzanne
AU - Huang, Tony Jun
AU - Mallouk, Thomas E.
PY - 2014/3/17
Y1 - 2014/3/17
N2 - The ultrasonic propulsion of rod-shaped nanomotors inside living HeLa cells is demonstrated. These nanomotors (gold rods about 300 nm in diameter and about 3 μm long) attach strongly to the external surface of the cells, and are readily internalized by incubation with the cells for periods longer than 24 h. Once inside the cells, the nanorod motors can be activated by resonant ultrasound operating at 4 MHz, and show axial propulsion as well as spinning. The intracellular propulsion does not involve chemical fuels or high-power ultrasound and the HeLa cells remain viable. Ultrasonic propulsion of nanomotors may thus provide a new tool for probing the response of living cells to internal mechanical excitation, for controllably manipulating intracellular organelles, and for biomedical applications. Ultrasonic propulsion: Metallic nanomotors can be internalized by incubation with HeLa cells for periods longer than 24 h (see picture). Once inside the cells, the nanomotors can be activated by resonant ultrasound operating at 4 MHz, and show axial propulsion as well as spinning. The HeLa cells remain viable.
AB - The ultrasonic propulsion of rod-shaped nanomotors inside living HeLa cells is demonstrated. These nanomotors (gold rods about 300 nm in diameter and about 3 μm long) attach strongly to the external surface of the cells, and are readily internalized by incubation with the cells for periods longer than 24 h. Once inside the cells, the nanorod motors can be activated by resonant ultrasound operating at 4 MHz, and show axial propulsion as well as spinning. The intracellular propulsion does not involve chemical fuels or high-power ultrasound and the HeLa cells remain viable. Ultrasonic propulsion of nanomotors may thus provide a new tool for probing the response of living cells to internal mechanical excitation, for controllably manipulating intracellular organelles, and for biomedical applications. Ultrasonic propulsion: Metallic nanomotors can be internalized by incubation with HeLa cells for periods longer than 24 h (see picture). Once inside the cells, the nanomotors can be activated by resonant ultrasound operating at 4 MHz, and show axial propulsion as well as spinning. The HeLa cells remain viable.
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U2 - 10.1002/anie.201309629
DO - 10.1002/anie.201309629
M3 - Article
C2 - 24677393
AN - SCOPUS:84896381087
SN - 1433-7851
VL - 53
SP - 3201
EP - 3204
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 12
ER -